Lab-on-a-Chip Made of Paper
Lab-on-a-Chip
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Color coding: This prototype of a new paper diagnostic test from Harvard University analyzes the glucose (left well) and protein (right well) content of urine; the top well is a control for the glucose assay. The beige part of the test paper has been treated with a hydrophobic polymer that channels the liquid into the wells. In this test, the paper was dipped in an artificial urine solution that contained glucose and a protein extracted from cow blood.
By taking advantage of the natural movement of liquid through paper, researchers at Harvard’s Whitesides Research Group may have found a way to make microfluidics technology much cheaper. The result could be disposable diagnostic tests simple and abundant enough for use in the developing world.
The field of microfluidics deals with the precise manipulation of tiny quantities of liquid. One of its most promising applications is the so-called lab-on-a-chip, which can work with much smaller fluid samples than larger devices require, potentially allowing for more portable diagnostic tools. But existing microfluidic chips are generally made from comparatively expensive materials like silicon, glass, or plastic and have tiny pumps and valves that can be difficult to manufacture.
